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this heterogeneity could explain why results from trials addressing classic neuropathic pain states do not translate to CIPNP Clinical trial designers in academia and industry are encouraged to implement sensory profiling in patient stratification to tailor the analgesic treatment according to the individual underlying mechanisms of CIPNP Mechanisms involved in CIPNP include disruption of axonal transport, altered ion channel and receptor activity, neuronal injury and inflammation, oxidative stress, and mitochondrial damage Suggestions for mechanism-based therapy of CIPNP include duloxetine for oxaliplatin-induced CIPNP, and combination of neuroprotective and anti-inflammatory substances for CIPNP caused by paclitaxel or vincristine Abstract Chemotherapy-induced peripheral neuropathic pain (CIPNP)a severe adverse effect observed in up to 80% of patients during treatment with antineoplastic drugslimits the tolerable dose of cytostatics, and can lead to discontinuation of chemotherapy

Role of beta-hydroxybutyric acid in the central regulation of energy balance

(Explained in next section) If a battery is charged or discharged at a higher C rate than it is rated for, it can overheat the battery

Record the reconstitution date and concentration, then refrigerate at 28C (3646F) away from direct light

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