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These findings are supported by work from Liu et al who similarly observed increased expression of synaptic signalling proteins in the hippocampus, and reductions in A and tau burden in the frontal cortex and hippocampus of AD mice with 4-week progressive ladder-climbing RT (15 climbs, progression from 15%75% MCL) (Liu et al., 2020)

The molecular basis of this continuous phenotypic switching involves the integration of complex signaling pathways such as TLRs, STAT proteins, and nuclear receptors, all of which are finely regulated by epigenetic modifications (13)

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A varied and balanced diet and a healthy lifestyle are important

Raffaella dV, Carmela C, Giovanna T