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459 In one crossover trial that included 126 patients with mild-to-moderate depression, supplementing with 248 mg elemental magnesium (as magnesium chloride) per day for six weeks resulted in a significant reduction in symptoms compared with no treatment

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Finally, genetic manipulation of ABCB6 revealed positive regulation of expression and activity of catalase, a heme-containing enzyme that catalyzes the decomposition of hydrogen peroxide (Baker et al

The second phase of the study involved 'high excreters' of urinary metal ions being given a further 6 rounds of chelation if allocated to the topical glutathione arm or 6 rounds of placebo if previously allocated to the topical placebo arm of the study

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