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EBioMedicine 22 , 191199 (2017)

In the absence of intracel-lular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) reacts with nucleophilic groups of cellular proteins, resulting in hepatotoxicity.The chemical and toxicologic characterization of the electro-philic nature of the reactive acetaminophen metabolite has led to the development of effective antidotescysteamine and N -acetylcysteine

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