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Herein, we summarized the mechanisms and delineated the regulatory network of ferroptosis, emphasized its dual role in mediating immune tolerance, proposed its significant clinical benefits in the tumor immune microenvironment, and ultimately presented some provocative doubts

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For example, in recurrent head and neck cancer, when organ sparring techniques are implemented, SBRT re-irradiation has demonstrated an acceptable toxicity profile and enhanced life quality outcomes

These processes operate across both spatial and temporal scales ( Figure 1

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