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The reliance of MDSCs on glucose and glycolytic metabolism has been extensively targeted, either by depleting glucose (e.g., 2-DG) or inhibiting glucose transporters and glycolytic enzymes such as GLUT3 or pyruvate dehydrogenases (e.g., DCA) (31, 32)

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Pancreatitis was reported as a rare serious adverse event in clinical trials

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4 Diurnal animal models of human age-related cataract Diurnal animals are active during the day, and sleep at night and therefore more closely resemble the activity of the average human than nocturnal and crepuscular animals

EFFECTS ON EXPERIMENTAL ANIMALS AND IN VITRO TEST SYSTEMS 8.1 Single exposure 8.1.1 LD 50 and LC 50 values 8.2 Short-term exposure 8.2.1 Oral 8.2.2 Inhalation 8.2.3 Dermal 8.2.4 Parenteral 8.3 Skin and eye irritation