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Important considerations when utilizing the cuprizone model for preclinical therapeutic efficacy studies as part of drug development studies include determining the appropriate time window for both the intervention and the endpoint readouts

Reduce tesamorelin dose to 1mg (from 2mg) for one week while maintaining GHRP dosing, then titrate back to 2mg gradually

[PMC free article: PMC3677810] [PubMed: 20148675] 60

The mechanism for this effect may have 2 components

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10.3389/fonc.2021.635472 255 McIlwainD