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Cornell University2025

Presence of ICAM-1, VCAM-1 and E-selectins on LECs enables the interaction with integrins present on tumor cells, facilitating their adhesion and migration through the lymphatic endothelium, and thus enabling their entrance into LVs (92, 98) ( Figure 3A )

Metabolic reprogramming and cross-talk The central roles of microbial metabolites in the metabolic reprogramming of cancer cells, which can mediate subsequent carcinogenesis and progression, have been underscored by emerging evidence