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Neurodegenerative Disease & Aging GSH levels decline with age and in neurodegenerative conditions, including Alzheimers, Parkinsons, and Huntingtons disease, in addition to stroke

Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

These observations indicate that ferroptosis can participate in UC through ER stress-mediated intestinal epithelial cell death, and the phosphorylation of NF-Bp65 inhibits ER stress-mediated ferroptosis in intestinal epithelial cells to alleviate UC

Iron accumulation-induced ROS, such as superoxide anion (O 2 -) and hydroxyl radical (OH), possess an unpaired electron at their outer orbit which allows them to react with all cellular components including proteins, lipids and nucleic acid