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It is surprising that no study has ever estimated the role of cysteine conjugates in toxicity of aminophenol and acetaminophen in cells, especially in situation when the entire description of toxicity of these two compounds remains still unclear (Brune et al

Moreover, Both treatment groups showed a noteworthy reduction in MASI score from the baseline (Manfreda et al., 2023)

B85502, Invitrogen) cultured in flat culture flasks were grown until confluent in Express Five SFM Medium (Gibco) supplemented with 200 mM l-glutamine (Sigma-Aldrich) and 1 Antibiotic-Antimycotic solution (Sigma-Aldrich) at 27 C

Abbreviations AIF: apoptosis-inducing factor ALF: acute liver failure ALT: alanine aminotransferase APACHE II: acute physiology and chronic health evaluation II APAP: acetaminophen AST: aspartate transaminase ATP: adenosine triphosphate DAMP: damage-associated molecular pattern DILI: drug-induced liver injury EndoG: endonuclease G FDA: Food and Drug Administration GDCA: glycodeoxycolic acid GDH: glutamate dehydrogenase GSH: glutathione HMGB1: high mobility group B1 HPLC: high-pressure liquid chromatography INR: international normalized ratio IV: intravenous JNK: c-Jun-N-terminal kinase KCH: Kings College Hospital KIM 1: kidney injury molecule 1 MELD: model for end-stage liver disease miRNA: microRNA mtDNA: mitochondrial DNA NAC: N -acetyl cysteine NAPQI: N -acetyl-para-benzo-quinone imine nDNA: nuclear DNA NK: natural killer NKT: natural killer T cells PO: oral SFN: sulforaphane SOFA: sequential organ failure assessment SULT: sulfotransferase UGT: UDP-glucoronosyl transferase Declarations Conflict of interest None Authors contributions Contributed to the manuscript by drafting the document, formatting the figures and tables, obtaining permission for use of previously published figures, and performing final editing of the content (EY), contributed to the manuscript by writing content and formatting the tables in the manuscript (AB), contributed to the manuscript by drafting sections of the document (MC), contributed to the manuscript by providing editing comments (MK), contributed to the manuscript by providing critical revision and administration during the manuscript writing (NP).

[DOI] [PubMed] [Google Scholar] 234.Rubinsztein DC

Curr Pharm Des 2022