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The gut-liver-kidney axis theory provides a systematic framework for understanding the complex nutritional metabolic disorders in DKD (7, 168)

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Consequently, fluid transparency was better in the coffee enema with PEG group than that in the PEG-only group in the mid and distal segments and the terminal ileum (p = 0.04, p = 0.007, and p = 0.002, respectively, Figure 1)

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