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Ultimately, the quality assessment determined that the selected studies met all the specified criteria and could be considered acceptable

Upon activation, the MLKL complex migrates to the plasma membrane, where its accumulation forms hotspots that open ion channels, causing cell swelling, membrane rupture, and the formation of pores

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The docking results suggest that the positively charged guanidinium group of Arg240 interacts strongly with the carboxylate group of L -tyrosine and L -DOPA, whereas the amine group (which is predominantly positively charged at the investigated pH) of the other two substrates is electrostatically repelled (Fig