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Rather than mixing the powder into a large glass of water and swallowing it immediately, the manufacturer and functional medicine practitioners recommend placing the powder directly in the mouth (or mixing it with a tiny sip of water) and holding it under the tongue or against the cheeks for 30 to 90 seconds before swallowing

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This might be responsible for the increased plasma GGT activity in chronic alcoholics

[2] Patients should contact their GP if they experience: Side effects from B12 injections (though these are rare and usually mild) Difficulty attending scheduled injection appointments, as missed doses may lead to symptom recurrence New symptoms developing during treatment Concerns about treatment effectiveness or duration Changes in other medications that might affect B12 absorption Suspected adverse reactions to B12 treatment can be reported through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)