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10.1016/j.phymed.2023.155291 51

Abstract Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation

Hepatotoxic effects of various polybrominated biphenyls in rats have also been reported [203,204]

doi: 10.1136/ard.2004.033241 262 SolomonDH

AMPKalpha2 deficiency exacerbates hypoxia-induced pulmonary hypertension by promoting pulmonary arterial smooth muscle cell proliferation

10 million MCF-7 or MCF-7 GPX4 null cells were mixed with Matrigel (Corning, Matrigel Matrix, 354230) at 1:1 ratio and injected subcutaneously into the mouse flanks