glutathione degradation Glutathione Degradation Is a Key

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and Safirstein, R

PMID: 40245705 Dis Model Mech A Drosophila chemical screen reveals targeting MEK and DGKa mitigates Ras-driven polarity-impaired tumour growth

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Rather, a summary of the types of organic compounds listed by Chasseaud is provided as representative of electrophilic xenobiotics that generate mercapturates when administered to experimental animals (rabbits and rats have been most extensively tested): halogenated benzenes, halogenated nitrobenzenes, other arylnitro compounds, chloro- S -triazines (herbicides), phenoltetrabromophthaleins, aralkyl halides, alkyl and alicyclic halides, sulfates and nitro compounds, allyl compounds, alkyl methanesulfonates, organophosphorus compounds, polycyclic aromatic hydrocarbons (via arene oxides), various ,-unsaturated compounds (esters, aldehydes, ketones, lactones, nitriles, nitro compounds, and sulfones), arylamines, arylhydroxylamines, carbamates, and related compounds

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