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Notably, elevated ratios of long-chain to very long-chain ceramide species in BALF correlate with inflammatory markers and lung disease severity, mechanistically linked to enhanced bacterial susceptibility and epithelial apoptosis (Zhang et al., 2008

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In particular, levels of L-arginine, L-proline, and L-glutamic acid were elevated, whereas glutathione, L-tyrosine, and L-phenylalanyl-L-proline levels were reduced

Among mixtures exposed to 640 M 4-HNE, unmarked WT and marked WT showed no significant difference in 4-HNE survival