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Elevated IGF-1 is a growth signal

Purines are key precursors for nucleic acid synthesis, and integral components of essential molecules involved in energy metabolism, such as NADP and NADPH (Figure 4)

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For instance, LTB4 and leukotriene E4 can bind to BLT1 (leukotriene B4 receptor 1) and GPR99, respectively, and the effects of LTC4, leukotriene D4, and leukotriene E4 are mediated by highly selective CysLT1 and CysLT2 receptors

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