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In addition, the mRNA and protein levels of SIRT1 in RA LFS are lower than normal FLS, and increased SIRT1 expression strikingly suppresses the invasiveness of RA FLS by inhibiting MMP1 and MMP13 expression (303)

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Contrarily, generally no new vessels grew in BPC 157treated rats (i.e., those that did form in the limbus did not make contact with the penetrated area) (Masnec et al., 2015), showing that BPC 157 therapy may acknowledge also the angiogenic privilege of the corneal avascularity as essential for corneal wound healing (Tshionyi et al., 2012)

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