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GLUTATHIONE PEROXIDASE PLAYS A CONTRADICTORY ROLE IN HYPERTENSION With respect to hypertension, glutathione peroxidase (GPx) has important functions in the reduction of peroxides that are reported to inactivate vasodilating NO and the decomposition of S-nitrosoglutathione (GSNO), which plays an important role in vascular homeostasis (33)

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455 Conversely, the effect of bosentan remains controversial, warranting more comprehensive investigations in large population cohorts

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