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It is important to acknowledge that translational challenges remain, especially due to BrM being often in accessible, unresected, or biopsy-limited, which restricts high-resolution profiling of spatially organized B cell states, TLS formation, and Breg-influenced niches (178)

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However, the fibrils formed were significantly shorter than those formed in the presence of copper, calcium and magnesium (Li et al., 2022)

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