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Insufficient oxygen negatively impacts folliculogenesis and oocyte maturation

This increases the chance of a successful pregnancy

Because correction of the underlying metabolic disorder generally results in correction of acid-base abnormalities and because of the potential risks of sodium bicarbonate therapy in the treatment of this disorder, administration of sodium bicarbonate is generally reserved for the treatment of severe acidosis (e.g., arterial pH less than 7-7.15 or serum bicarbonate concentration of 8 mEq/L or less)

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A 2004 study published in the American Journal of Obstetrics and Gynecology suggests vitamin B12 deficiency during pregnancy may increase spina bifida risk in the fetus/baby