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Thyroid follicular cells themselves can aberrantly express MHC class II and co-stimulatory molecules (B7.1/CD80), enabling them to act as non-professional antigen-presenting cells (APCs) and amplify the autoimmune cascade

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On the other hand, those with severe kidney problems taking high amounts of B12 may see a high level of toxicity since the excess vitamin B12 wont get eliminated from the body easily

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Deep-reaching acceleration of global mean ocean circulation over the past two decades