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The topical use of SSA or SSC was shown to enhance the condition of atopic dermatitis-like skin lesions in 2, 4- dinitrochlorobenzene (DNCB) mice ( Among the natural phytochemicals, the total glucosides of paeony (TGP), extracted from Paeonia lactiflora Pall

doi:10.4103/0976-3147.153213 Branch WT, Barton JJ

The MMP paradox Matrix metalloproteinases, or MMPs, are enzymes that break down collagen and other structural proteins in the skin

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The elevated extracellular levels of glutamic acid observed in withdrawal, together with supersensitivity of NMDA receptors, may expose vulnerable neurons to excitotoxicity, possibly contributing to the neuronal loss sometimes observed in chronic alcohol dependence

To alternatively validate binding and inhibition of the two main targets, we used a protein expression methodology that enables the in situ activation in living cells 26