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In brief, CAFS releases cytokines, chemokines and effector molecules including TGF-, IL-6, stromal-derived factor-1 (SDF-1), CC chemokine ligand 2 (CCL2), C-X-C chemokine ligand 12 (CXCL12), prostaglandin E2 (PGE2) and indoleamine 2,3-dioxygenase (IDO) along with VEGF to actuate immunosuppression in the TME [114]

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Cardiovascular diseaserisk factors involve various genetic elements, particularly the levels of lipoproteins in the blood

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