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For high-risk PAINS compounds, a stricter validation framework must be established, including multiple experimental methods to verify it

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Cancer Res 2001 61 : 49614965 Palmer K, Hitt M, Emtage PC, Gyorffy S, Gauldie J

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The morphology of AgNPs influences uptake and cellular stress, as spherical forms typically internalize more efficiently than rods or triangles, which can disrupt cell membranes and cytoskeleton