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Levels of evidence and grades of recommendation The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system (Table 1) was applied to grade the evidence and recommendations

Firstly, combination therapy: The synergistic effects of combining these ESCM with conventional treatments (e.g., chemotherapy, radiotherapy, immunotherapy) should be investigated to enhance therapeutic efficacy and mitigate side effects

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Von Frey test We assessed mechanical pain sensitivity by observing the paw withdrawal reaction to von Frey filament stimulation