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and H.S

The released SIM inhibits HMGCR, reducing downstream mevalonate pathway metabolites, such as IPP, resulting in GPX4 dysfunction, impaired lipid repair capacity, and LPO accumulation, ultimately inducing ferroptosis and establishing a comprehensive lipid metabolism regulatory axis

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Use of ranks in one-criterion variance analysis

We analyzed the relationship between the phenotype and variant site, mutation type, and zygosity