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Postirradiation sensitization of mammalian cells by the thiol-depleting agent dimethyl fumarate

For example, the mutant presenilin 1, one of the main causes of familial AD, was found to cause a dysfunction in lysosomal acidification, leading to elevated lysosomal pH values 125 , lysosomal proteolysis injury, and AD-like pathologic alterations 126

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Its systemic (all over)