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This review systematically explores the key mechanisms underlying ferroptosis, including polyunsaturated fatty acid-containing phospholipid (PUFA-PL) peroxidation, iron metabolism, and mitochondrial dysfunction

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10.1016/j.trsl.2022.04.002 69 LuoZ.LvS.LouF.YanL.XuJ.KangN.et al

Consequently, iron deficiency or impaired metabolism can lead to damage to nigrostriatal neurons and disruption of the dopamine system, which is a primary pathobiological factor in restless legs syndrome (RLS) [73, 74]

While NSAIDs and other lifestyle factors can contribute to glutathione depletion, proactive strategiesincluding diet, exercise, and stress managementcan help support the bodys natural antioxidant defenses

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