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In symptomatic SOD1 G93A mice, because no decrease in Gpx4 mRNA level was observed, the deficiency of Gpx4 likely occurred at the post-transcriptional level

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Simultaneously, some tumor cells, owing to specific mutations, elevated ROS levels and other unique biological features, exhibit ferroptosis susceptibility, with their survival hinging on the ferroptosis defense system (108)

In the oxidative phase , glucose-6-phosphate is converted to ribulose-5-phosphate, and NADPH is produced