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As our understanding of flavonoids role in regulating ferroptosis deepens, research should not only explore the involved molecular pathways but also address the practical aspects of delivering these compounds to specific cells, which is crucial for translating research into effective clinical interventions

Future longitudinal studies that correlate symptoms fluctuations with alterations in these pathways could also help identify new therapeutic targets

Conversely, individuals with high PEM/E , low NEM/N and low AI would be least vulnerable (most resilient) to SUD ( Figure 3 To our initial analysis, we added CI as an additional personality trait, modulated by a circuit including glutamatergic neurons from the ventromedial prefrontal cortex and the posterior cingular cortex that innervate the ventral striatum (nucleus accumbens) and, as with AI , is also moderated by the D 4 R gene, and by the gene of the enzyme catechol- O -methyltransferase ( Figure 3 )

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In these tissues, glucose uptake is mediated by GLUT proteins other than GLUT-4 and so does not require insulin