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The perspective presented here expands the mitohormesis concept by emphasizing that it is optimally activated by a balanced oscillation between mitochondrial stressor and recovery phases, rather than relying on one phase over the other

This discrepancy has led to the question, How long is long enough? Several reports have described truncation of oral acetylcysteine therapy in some patients

rapid NAD+ infusions often cause flushing or dizziness, slow titration improves tolerance

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Pharmaceutics 15 (7), 1972 (2023)

This helps explain why patients with extensive surgical trauma or prolonged ischemia often develop a systemic inflammatory response that parallels septic shock, even in the absence of infection (54)