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The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

The proposed mechanisms behind BPC-157 center on four distinct biological processes, which are the formation of new blood vessels, the reorganization of the extracellular matrix, the proliferation of fibroblasts, and inflammatory regulation

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doi: 10.1136/lupus-2023-000987 118 ReddyVJayneDCloseDIsenbergD

The advantage to starting earlier is that its easier to prevent the signs of aging, then it is to reverse them