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In support of these conclusions, the weak ferroptosis inhibitor ferrostatin-1 did not protect and the more potent inhibitor UAMC-3203 partially protected through off-target effects in the absence of relevant LPO [81]

Two structures of ME2-inhibitor complexes demonstrate that 5,5-Methylenedisalicylic acid (MDSA) and embonic acid (EA) bind allosterically to ME2s fumarate-binding site

Furthermore, studies have identified Nrf2 as a promising antioxidant target for depression treatment (Liao et al., 2020)

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Potential Mechanisms in Preclinical Research BPC-157 is a multitasker, as revealed in animal and cell-based research