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Rotate sites systematically with each dose to prevent irritation or tissue damage [7] [9]

Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements

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Chronic use of high-dose supplements can potentially affect blood sugar regulation, promote abnormal tissue growth, and contribute to joint and nerve issues

But uncontrolled organ growth particularly gut distension (sometimes called "GH gut" in bodybuilding) and potential cardiac hypertrophy is a well-documented concern with prolonged growth factor elevation