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First clinically described over 120 years ago, MS is now generally accepted be an inflammatory, autoimmune demyelinating disease of the CNS in which an adaptive immune response targets unknown CNS antigens, resulting in myelin damage, and subsequent impaired conduction of action potential and axonal degeneration (Friese et al., 2014

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However, further research is required to decipher micronutrient deficiency-induced ROS generation, perception, and associated downstream signaling events, leading to the development of antioxidant responses in plants