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Description

Upon careful estimation, we determined that assigning 135 patients to both the study and control groups would yield more than 80% power to detect between-group differences

And while more adults experience RLS, it's estimated that between 2% and 4% of children may also have the condition (2)

Is this a known problem

New England Journal of Medicine , 368: 1575-1584 Zhu W, et al

We prioritized evidence derived from human clinical trials, placing a distinct emphasis on randomized controlled trials (RCTs) and comprehensive systematic reviews published from 2015 onwards, reflecting the most recent and rigorous advancements in the field