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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal, further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly (for parenteral supplementation) or daily (for oral supplementation)

A total of 221 subjects (37 males and 184 females) diagnosed by experienced neurologists as migraineurs according to the International Classification of Headache Disorders criteria (ICHD-3), aged between 18 and 72 years (mean standard deviation: 41.9 11.3 years), served as case group

As originally described by Kosower [8], diamide chemically oxidizes the GSH pool without generating ROS during the reaction, which allowed us to alter the antioxidant status without increasing the ROS load directly (as would H 2 O 2 treatment)

doi: 10.1021/acs.molpharmaceut.0c00566 207 AnbazhaganRMuthusamyGKrishnamoorthiRKumaresanSRajendra PrasadNLaiJ-Yet al