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Oral precursors such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) must be absorbed by the intestine and then metabolized by the liver to be converted into NAD+

The pivotal mouse study used subcutaneous injection, not oral dosing a real mismatch between the tested route and typical community/commercial use

six animals from the LD control, WD control, and WD/LD-V groups and five animals from the WD/LD-T group were euthanized the first day

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