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Figure 4 Figure 5 Molecular docking simulation validated the interaction between DZXI compounds and their targets in silico To calculate potential binding capacity between five DZXI active compounds [including scutellarin, 3,4-O-dicaffeoylquinic acid, 3,5-O-dicaffeoylquinic acid, 4,5-Odicaffeoylquinic acid, erigoster B which are highly exposed systematically in vivo (Guo et al., 2018

In comparison, in the high-overdose patient (D), the maximum number of necrosed cells was 1,754 out of 5,114 (34.29%) without zonation and increased to 1,806 when 50% zonation was applied (see Figure 4)

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Conditions that interfere with absorption include: Atrophic gastritis Pernicious anemia Gastrointestinal disorders such as Crohns disease or celiac disease These conditions can increase the risk of B12 deficiency even in individuals with a balanced diet

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