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Patients with MS may suffer from nerve injury affecting the ocular muscles, including those controlling blinking, potentially decreasing blinking frequency and aggravating tear evaporation, thereby triggering or worsening DED (Li et al., 2022a)

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Therefore, genomic, proteomic and metabolomic analysis should be the main strategies utilized in order to determine the pharmacodynamics of mangiferin

Accumulating evidence indicates that inflammatory mediators promote iron accumulation in microglia, which in turn drives M1-like polarization characterized by elevated secretion of pro-inflammatory cytokines and enhanced ROS production (33)