Experimental studies have shown that oral supplementation with glutamine can significantly decrease the severity of chemotherapy-induced stomatitis, an important cause of morbidity in the treatment of patients with cancer,[85,86] although the dose given and duration of therapy varies widely upon pathological conditions.[87] Other modalities of prevention of chemotherapy-induced mucositis, like oral cooling, granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor and laser, are available, none of them have uniform efficacy.[88] Studies in mice suggest that alanyl-glutamine, not glutamine, speeds intestinal recovery when compared in 5-FU-treated mice, predominantly by enhancing mitotic activity and crypt length.[89] To evaluate the effect of therapeutic interventions in patients with chemotherapy-induced mucositis, testing intestinal permeability via the measurement of[51] Cr-EDTA urinary excretion after oral challenge may be useful as shown in some experiments.[90,91] GLUTAMINE AND PROTECTION AGAINST ANTHRACYCLINE-INDUCED CARDIOTOXICITY Glutamine supplementation maintained cardiac GSH levels in animal models given methotrexate or CP
4 Lakhanpal, M.L
Hiddemann W, Buechner T, Andreeff M , Woermann B, Clarkson B
10.1007/s11910-005-0056-6 Curr
Molecular Weight: 1419.53 g/mol
Adults supporting recovery from training, physical stress, or repetitive strain People looking to maintain joint comfort and connective tissue health over time Those supporting gut barrier integrity alongside a broader tissue repair routine Anyone consolidating a multi-product recovery stack into a single daily capsule Suggested Use Take 2 capsules once or twice daily, with or without food
