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Overall, these preclinical and clinical data highlight the anti-HCC potential of all-trans retinoic acid, and further clinical trials, including phase 3 clinical trial, should be considered to evaluate the optimal therapeutic regimen for this drug in HCC patients

doi:10.1001/jama.2013.2107 Lamas GA, Anstrom KJ, Navas-Acien A, et al

The quick summary is remarkably fun and occasionally (unintentionally?) hilarious

Dermatology and therapy

Hyperpigmentation: Glutathione and Glycerin help reduce hyperpigmentation and dark spots on the skin

One important unanswered question is if sleep recovery following deprivation can restore the epigenome to its initial state