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J Colloid Interface Sci 323(1):98104

38 , e101196 (2019)

IMP activates toll-like receptor 4 (TLR4) in MCs, leading to the activation of the inflammatory NF-B signaling pathway and the release of inflammatory factors such as TNF-, IL-6, and IL-1

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Cell types responding to the two IGF factors include adipocytes, chondrocytes, epithelial cells, fibroblasts, glial cells, hepatocytes, muscle cells, and osteoblasts

Intestinal I/R causes disruptions in intestinal flora and significant alterations in metabolites