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Mild reactions seen in oral CBD studies include the following: Digestive problems like diarrhea, nausea, vomiting, constipation, stomach pain, and bloating Fatigue Changes in appetite Headaches Weight changes (gain or loss) Skin irritation Sleep problems like insomnia Dizziness or lightheadedness Fever Less common but serious complications of oral CBD include liver stress, producing abnormal liver function test results

This loss of cellular ATP during starvation can be prevented by the presence of a variety of suitable exogenous energy substrates [62, 70] including hexoses, monocarboxylates, fatty acids, amino acids and nucleosides (Table 6)

Prog Neuro-Psychopharmacol Biol Psychiatry 102:109958 Leclercq S et al (2021) Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms

Smith ZD, Meissner A

PMID: 68 ChangCHQiuJOSullivanDBuckMDNoguchiTCurtisJDet al

Gastroenterology 157 , 13231337 (2019)