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Immunofluorescence A total of 0.5 10 4 cells were seeded on confocal NEST glass-bottom Petri dishes (NEST, Wuxi, China) for a 24-hour incubation

Indeed, inhibiting leukotriene signaling during MI has shown to impede excessive inflammation with reduced IL-1 expression, diminished leukocyte infiltration and to improve cardiac function in a murine model of MI [27]

Based on this neutrophils can also be used as targets for anticancer therapy (5), the main strategies include reducing neutrophils in tumor sites by inhibiting neutrophil recruitment and migration, enhancing the antitumor activity of neutrophils, and altering neutrophil polarity

Marignani M, Fave DG, Mecarocci S, Bordi C, Angeletti S, DAmbra G, et al

Additionally, simvastatin is also highly lipophilic and can cross the bloodbrain barrier