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Importantly, HUVEC-BOs recapitulated many aspects of neurogenesis and gliogenesis in human cortical development, had greater functional maturation and synaptic connections, and showed increased expression of P-glycoprotein, an important efflux transporter in brain endothelial cells of the blood-brain barrier (BBB)

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Notably, 4-HNE can activate the mitochondrial ROS-mediated AKT/NF-B signaling pathway and increase MMP2 production in VSMCs (123)

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