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Weekly intra-articular injections of the HDAC inhibitor TSA reduced the expression of these genes, suggesting that HDAC activity contributes to cartilage catabolism

Clinical studies confirm that up to 500 mg daily is safe for up to 2 months

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doi: 10.1038/nrgastro.2017.72 20 XieGWangLChenTZhouKZhangZLiJet al

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Effects of transcranial direct current stimulation (t-DCS) of the cerebellum on pain perception and endogenous pain modulation: a randomized, monocentric, double-blind, sham-controlled crossover study