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In neurons, the enzyme SARM1 is rapidly activated under conditions of metabolic stress or axonal injury, triggering swift NAD + cleavage and initiating axonal degeneration

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However, it has been demonstrated that SCFAs stimulate the expression of leptin in adipocytes by activating the free fatty acid receptor 3 (FFAR3) 84 , which provides a basis for future studies on the association between bifidobacteria and leptin

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