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Total cholesterol increased by an average of 33% in the participants of the study, resulting in 61% of participants with total cholesterol classified as high and another 17% who were borderline high. Over a 2-year follow-up period, average total cholesterol decreased, but remained above the high total cholesterol cutoff values

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Likewise, copper is the cofactor of metabolic enzymes (e.g., cytochrome c oxidase in mitochondria, CuZnSOD in cytosol) and it catalyzes the enzymatic activity of key enzymes of the secretory pathway (reviewed in Polishchuk and Lutsenko, 2013

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